The most recent research grants funded by the CFIDS Association of America have supported six principal investigators and the projects that were evaluated to have the highest scientific and strategic merit among those submitted during our 2008 cycle. We awarded funding totaling $647,940 to support these research studies, thanks to the generosity of our donors. This report builds on earlier progress updates and we’ll continue to keep you informed about additional outcomes you made possible. A condensed version of this report was originally published in the summer-fall 2011 issue of our print publication, SolveCFS. You can find links to other materials about Dr. Medow’s research at the bottom of this page and links to reports on the other five projects here: http://www.research1st.com/2011/11/28/accelerate/.
Institution: New York Medical College
- Julian Stewart, MD: New York Medical College
- Benjamin Natelson, MD: Beth Israel Medical Center
Project Title: Splanchnic vasoconstriction is impaired by microbiomic nitric oxide production reducing cerebral blood flow in CFS
Objective: To determine if upright posture causes neurocognitive deficits as a result of impaired cerebral blood flow and modulation of nitric oxide and reactive oxygen species.
Funding: Application to NIH pending review.
- Decreased upright cerebral blood flow and cerebral autoregulation in normocapnic postural tachycardia syndrome. AJP Heart and Circulatory Physiology. 2009. Link: http://bit.ly/uCeKP5
- Respiration drives phase synchronization between blood pressure and RR interval following loss of cardiovagal baroreflex during vasovagal syncope. AJP Heart and Circulatory Physiology. Nov. 12, 2010. Link: http://bit.ly/uqkCDX
- Reactive oxygen species from NADPH and xanthine oxidase modulate the cutaneous local heating response in healthy humans. Journal of Applied Physiology. March 24, 2011. Link: http://bit.ly/rVIOzm
- Cutaneous constitutive nitric oxide synthase activation in POTS with splanchnic hyperemia. AJP Heart and Circulatory Physiology. June 3, 2011. Link: http://bit.ly/rNmujp
- Increasing orthostatic stress impairs neurocognitive functioning in CFS and POTS and is not related to cerebral blood flow velocity. Clinical Science. E-pub ahead of print on Sept. 15, 2011. Link: http://www.clinsci.org/cs/122/cs1220227.htm (See summary below.)
- Additional data being analyzed; manuscripts in preparation.
Summary of Clinical Science publication:
Orthostatic Stress Impairs Cognition: 16 subjects who met criteria for CFS and postural orthostatic tachycardia syndrome (POTS) were compared to 20 healthy volunteers. Subjects performed cognitive testing while lying flat, then while tilted to 15, 30,45,60 and 70 degrees for 10 minutes at each angle. The test was stopped if the subject became hypotensive or requested to stop. The two groups had similar drop-out rates. At baseline, the subjects had increased heart rate and respiratory rates, but comparable intelligence and cognitive performance. However, during the tilt, compared to controls the CFS-POTS subjects cognitive performance worsened as orthostatic stress increased. The subjects had decreased accuracy and longer normalized reaction time during difficult tasks imposed on orthostatic stress.
What has the Association’s support has meant to your research?
Dr. Medow: “In addition to the obvious benefits of receiving financial support from the CFIDS Association that helps to defray the cost of conducting research on CFS, my research has allowed me to interact with many CFS subjects during these studies, which has put a ‘personal face’ on this syndrome. This has increased my appreciation for the need to provide answers to the many unanswered questions about the cause of and the mechanisms that underlie symptoms of CFS. I have also enjoyed providing information about CFS through our scientific publications, and the webinars and scientific meetings arranged by the Association. Lastly, the interactions that I have had with other health care professionals I have met through the Association have provided useful insights into CFS beyond the scope of my own investigations.”
- “The outs and ins of OI,” review of research about orthostatic intolerance and clinical tips for those who have OI (Research1st, June 19, 2011)
- “Association Research program update,” webinar by Dr. Suzanne Vernon (July 8, 2010) (Webinar slides)
- “Going with the flow — blood flow that is,” webinar by Dr. Medow (March 10, 2010) (Webinar slides: http://www.cfids.org/webinar/oi-slides-32510.pdf)
- “Association researchers making headway,” update by Dr. Suzanne Vernon about Dr. Medow’s project and others funded by the Association (Jan. 6, 2010)
- “Slow Flow,” a review of two studies (including one from Dr. Medow's group) about impaired blood flow to the brain (CFIDSLink, July 1, 2009)
- “Banbury Meeting: Perfect setting, packed agenda, productive dialogue, promising outcomes,” report on the Association's mid-term investigator meeting (Research1st, Oct. 6, 2009)
- “Going with the flow,” a profile of Dr. Medow and his research (CFIDS Chronicle, winter 2009)
- “Association launches first funded CFS research network,” article by Kim McCleary about the Association's first investigator meeting (Research1st, Feb. 1, 2009)
- Sponsored research program of the CFIDS Association of America, description of the Association’s program including descriptions of grants funded (Research1st, May 2011, with periodic updates)